Many years ago I was relaxing on Koh Samui when this super straight guy came up to me and asked if it was possible that someone had poisened his wife as she was acting strange.  On questioning found that they had eaten mushroom omlettes (two serves as they were so good) so we told him what mushroom omlettes were and convinced him that the best thing whether he agreed with drugs or not was to relax and enjoy it so he had a nice trip.
Must have worked.  They ordered them the net night too.